Leslie Mann Details Judd Apatow’s Ozempic Weight Gain, Not Weight Loss

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After years of feeling “very skeptical of starting a GLP-1” actress Chrissy Metz decided it was time to give it a shot. “I’m just very diligent about what and how things work within the body,” the This Is Us alum explained in an exclusive August 2026 interview with E! News, “and I’m like, ‘Oh, I don’t know what that’s gonna be like.'” 
But after listening to a friend’s “very thorough” research, she teamed with telehealth company Ro. 
“I’ve been on diets for a very, very long time, since I was a kid, and I know I can lose weight,” she explained, “but I didn’t know that I could quiet food noise and I didn’t know there were other factors. There’s so much shame around being in a bigger body, so just knowing that I wasn’t doing it purely for vanity’s sake.” 

“It’s helped with inflammation,” she noted. “It’s helped with just overall health lab work and blood work and just generally just an overall feeling of space and creativity that the food noise has quieted. It opens up just more ability to be present.”

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